Links and Files
Authors
- Venkatraman, Sripathy
- Tweedie, Scott
- McLaws, Mark
- Lathbury, David
Abstract
Utility of continuous flow chemistry in a carboxylation reaction and palladium-mediated α-arylation reaction is described. A two-step carboxylation reaction of an aryl group involving an anion formation, followed by quench with gaseous carbon dioxide was developed on small scale using HDPE tubes in a dry ice/acetone bath. The process was then scaled up using stainless steel tubes of larger diameter and static mixers to process 22 kg of material in a regular lab in 88% yield. Similarly, a continuous flow process for a hazardous palladium-mediated α-arylation reaction which had a significant exotherm during heat up was developed.
Journal
ACS Symposium Series. Volume 1181, 2014, 441-453
DOI
10.1021/bk-2014-1181.ch016
Type of publication
chapter book
Affiliations
- Albany Molecular Research Inc.
Article Classification
Book Chapter
Classification Areas
- Intermediate