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Authors
- Rogers, Amanda
- Ierapetritou, Marianthi Eden, Mario R. Siirola, John D.
- Towler, Gavin P.
Abstract
The pharmaceutical industry currently faces economic and regulatory challenges associated with process development. Process systems engineering (PSE) tools can play a role in developing robust and economically efficient manufacturing processes. However pharmaceutical companies have lagged behind other specialty chemical manufacturers in the adoption of these tools. This is in part due to the challenges associated with modeling and optimization of solids-based processes. However recent advances in the modeling of particulate processes and the optimization of complex process models have created opportunities to apply PSE methods to pharmaceutical manufacturing processes. This work will provide an overview of the challenges associated with modeling and optimizing particulate processes and discuss opportunities for improving pharmaceutical process development through the use of concepts from process systems engineering.
Journal
Computer Aided Chemical Engineering. Volume 34,, 2014, 144-149
DOI
10.1016/B978-0-444-63433-7.50015-8
Type of publication
Chapter Book
Affiliations
- Rutgers, The State University of New Jersey
Article Classification
Review article
Classification Areas
- Modeling