Continuous Manufacturing Knowledge Center
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  • Article

    100% visual inspection of tablets produced with continuous direct compression and coating

    Links and Files https://doi.org/10.1016/j.ijpharm.2022.121465 Authors Barimani, Shirin Sibanc, Rok Tomazevic, Dejan Meier, Robin Kleinebudde, Peter Abstract Visual appearance…
  • Article

    3D Printed Reactors for Synthesis of Active Pharmaceutical Ingredients in Continuous Flow

    Links and Files https://doi.org/10.1021/acs.oprd.0c00228 Authors Maier, MC Valotta, AHiebler, K Soritz, S Gavric, K Grabner, B Gruber-Woelfler, H Abstract Advances in flow chemistry…
  • Article

    3D printing and continuous flow chemistry technology to advance pharmaceutical manufacturing in developing countries

    Links and Files https://doi.org/10.1016/j.arabjc.2020.09.020 Authors Sagandira, CR Siyawamwaya, M Watts, P Abstract The realization of a downward spiralling of diseases in developing…
  • Article

    7-Step Flow Synthesis of the HIV Integrase Inhibitor Dolutegravir

    Links and Files https://doi.org/10.1002/anie.201802256 Authors Ziegler, RE Desai, BKJee, JA Gupton, BF Roper, TD Jamison, TF Abstract Dolutegravir (DTG), an important active pharmaceutical…
  • Article

    A brief review on Process Analytical Technology (PAT)

    Links and Files https://journals.innovareacademics.in/index.php/ijcpr/article/view/10606 Authors Mali, Akash Jagtap, Monali Karekar, P. Maruska, A Abstract Process analytical technology…
  • Article

    A Combined Feed-Forward/Feed-Back Control System for a QbD-Based Continuous Tablet Manufacturing Process

    Links and Files https://doi.org/10.3390/pr3020339 Authors Singh, Ravendra Muzzio, Fernando J Ierapetritou, Marianthi Ramachandran, Rohit Abstract Continuous pharmaceutical manufacturing…
  • Article

    A Compact Device for the Integrated Filtration, Drying, and Mechanical Processing of Active Pharmaceutical Ingredients

    Links and Files https://doi.org/10.1016/j.xphs.2019.12.011 Authors Capellades, G Neurohr, CAzad, M Brancazio, D Rapp, K Hammersmith, G Myerson, AS Abstract Recent changes in…
  • Article

    A Comparative Investment Analysis of Batch Versus Continuous Pharmaceutical Manufacturing Technologies

    Links and Files Rossi_JPI_Article.pdf Authors Clifford V. Rossi (University of Maryland) Abstract Purpose This study examines the risks and economics associated with investing in continuous…
  • Article

    A comparative review of multi-rate moving horizon estimation schemes for bioprocess applications

    Links and Files https://doi.org/10.1016/j.compchemeng.2020.107219 Authors Elsheikh, Mohamed Hille, Rubin Tatulea-Codrean, Alexandru Kramer, Stefan Abstract Advanced control and monitoring…
  • Article

    A Comparison Between Lab-Scale and Hot-Melt-Extruder-Based Anti-inflammatory Ointment Manufacturing

    Links and Files https://doi.org/10.1208/s12249-020-01738-5 Authors Thakkar, R Ashour, EAShukla, A Wang, R Chambliss, WG Bandari, S Murthy, N Repka, MA Abstract Hot-melt extrusion…
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