overcoming poor solubility in active ingredient processing

Hi, With regards to drug substance solubility, you can use heat and pressure to allow the solids to dissolve, which can then be pumped into the CM system.

Also you can pump a slurry through a heat exchanger to raise the temperature and achieving the required solubility, possibly under pressure. This limits the time spent by the materials at elevated temperature.

You can also attempt your chemistry in the slurry phase, we have been successful running even photochemistry as a slurry.

When looking at fixed bed hydrogenation, we do require all solids to be dissolved. We can often run the process more dilute than would normally be used during the analogous batch process, and simply remove the excess solvent after the process for immediate re-cycling back into the process.

Hi, With regards to drug substance solubility, you can use heat and pressure to allow the solids to dissolve, which can then be pumped into the CM system.

Also you can pump a slurry through a heat exchanger to raise the temperature and achieving the required solubility, possibly under pressure. This limits the time spent by the materials at elevated temperature.

You can also attempt your chemistry in the slurry phase, we have been successful running even photochemistry as a slurry.

When looking at fixed bed hydrogenation, we do require all solids to be dissolved. We can often run the process more dilute than would normally be used during the analogous batch process, and simply remove the excess solvent after the process for immediate re-cycling back into the process.