overcoming poor solubility in active ingredient processing

The use of solubilizers and stabilizers in the formulation, together with some processes like producing  solid dispersions by melt extrusion or spray dry techniques are ways to deal practically with the issue of poor soluble APIs. In our group at Rutgers, we are actually working with two methodologies (impregnation poorly soluble APIs in porous carriers and melt coating with only 5-10% of  a surfactant) that proved to be excellent methods with some advantages over melt extrusion and spray dry. We have some patents and publications validating the processes for those interested to get more information. 

The use of solubilizers and stabilizers in the formulation, together with some processes like producing  solid dispersions by melt extrusion or spray dry techniques are ways to deal practically with the issue of poor soluble APIs. In our group at Rutgers, we are actually working with two methodologies (impregnation poorly soluble APIs in porous carriers and melt coating with only 5-10% of  a surfactant) that proved to be excellent methods with some advantages over melt extrusion and spray dry. We have some patents and publications validating the processes for those interested to get more information.