overcoming poor solubility in active ingredient processing

Hi Alan, this many times can be a challenging part during drug substance synthesis. In my experience what has proven to be the most successful, is to have a co-solvent (mixture of solvents) if your material is not soluble in a single solvent system. Another option, which is very uncommon, would be to adjust the pH of the solvent system provided your materials won't degrade under the given pH conditions.

Hi Alan, this many times can be a challenging part during drug substance synthesis. In my experience what has proven to be the most successful, is to have a co-solvent (mixture of solvents) if your material is not soluble in a single solvent system. Another option, which is very uncommon, would be to adjust the pH of the solvent system provided your materials won't degrade under the given pH conditions.