Chapter Book (1-3 of 3)

1. Challenges and Opportunities in Pharmaceutical Manufacturing Modeling and Optimization

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   09 Jun 2023 | Contributor(s):: Rogers, Amanda, Ierapetritou, Marianthi Eden, Mario R. Siirola, John D., Towler, Gavin P.

   The pharmaceutical industry currently faces economic and regulatory challenges associated with process development. Process systems engineering (PSE) tools can play a role in developing robust and economically efficient manufacturing processes. However pharmaceutical companies have lagged behind...

2. An Overview of Pharmaceutical Manufacturing for Solid Dosage Forms

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   09 Jun 2023 | Contributor(s):: Sacher, Stephan, Khinast, Johannes G.

   In this chapter, the main processing steps and manufacturing aspects of solid dosage forms are described and the relevant literature is reviewed. Starting with powder feeding, powder blending, granulation (dry and wet), and drying the most important unit operations to make compactable granules...

3. A Digital Twin for Process Optimisation in Pharmaceutical Manufacturing

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   09 Jun 2023 | Contributor(s):: Gerogiorgis, Dimitrios I., Castro-Rodriguez, Daniel

   Organic synthesis is a critical step in producing any Active Pharmaceutical Ingredient (API): it encompasses a series of organic (mostly catalytic) reactions and separations, whose purpose is to arrive at a solution of a target molecule, which must then undergo crystallisation for purification,...