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A review on the taste masking of bitter APIs: hot-melt extrusion (HME) evaluation
09 Jun 2023 | Contributor(s):: Maniruzzaman, M, Boateng, JSChowdhry, BZ, Snowden, MJ, Douroumis, D
The majority of active pharmaceutical ingredients (APIs) found in oral dosage forms have a bitter taste. Masking the unpleasant taste of bitter, APIs is a major challenge in the development of such oral dosage forms. Taste assessment is an important quality-control parameter for evaluating...
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A Perspective on Continuous Flow Chemistry in the Pharmaceutical Industry
09 Jun 2023 | Contributor(s):: Baumann, M, Moody, TSSmyth, M, Wharry, S
Continuous flow manufacture is an innovative technology platform, which is gaining momentum within the pharmaceutical industry. The key advantages of continuous flow include faster and safer reactions, which can be more environmentally friendly, smaller footprint, better quality product, and...
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A comprehensive overview of extended release oral dosage forms manufactured through hot melt extrusion and its combination with 3D printing
09 Jun 2023 | Contributor(s):: Nashed, Nour, Lam, Matthew, Nokhodchi, Ali
Oral dosage formulations are considered to be the most convenient pharmaceutical dosage forms for almost all ages because of their simplicity and non-invasive administration compared to other dosage forms. To improve therapeutic efficacy and avoid frequent daily doses, extending drug release...
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A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries
09 Jun 2023 | Contributor(s):: Gambacorta, G, Sharley, JS, Baxendale, IR
Due to their intrinsic physical properties, which includes being able to perform as volatile liquids at room and biological temperatures, fragrance ingredients/intermediates make ideal candidates for continuous-flow manufacturing. This review highlights the potential crossover between a...
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3D printing and continuous flow chemistry technology to advance pharmaceutical manufacturing in developing countries
09 Jun 2023 | Contributor(s):: Sagandira, CR, Siyawamwaya, M, Watts, P
The realization of a downward spiralling of diseases in developing countries requires them to become self-sufficient in pharmaceutical products. One of the ways to meet this need is by boosting the local production of active pharmaceutical ingredients and embracing enabling technologies. Both 3D...
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A brief review on Process Analytical Technology (PAT)
09 Jun 2023 | Contributor(s):: Mali, Akash, Jagtap, Monali, Karekar, P., Maruska, A
Process analytical technology (PAT) has been defined as a mechanism to design, analyze and control pharmaceutical manufacturing processes through measurement of critical process parameters which affect critical quality attributes. PAT checks the quality of raw material attributes both physically...