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1. Matrix-assisted cocrystallization (MAC) simultaneous production and formulation of pharmaceutical cocrystals by hot-melt extrusion

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   23 Jul 2024 | Contributor(s):: Boksa, Kevin, Otte, Andrew, Pinal, Rodolfo

   A novel method for the simultaneous production and formulation of pharmaceutical cocrystals, matrix-assisted cocrystallization (MAC), is presented. Hot-melt extrusion (HME) is used to create cocrystals by coprocessing the drug and coformer in the presence of a matrix material. Carbamazepine...

2. Applications of Supercritical Anti-Solvent Process in Preparation of Solid Multicomponent Systems

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   09 Jun 2023 | Contributor(s):: Liu, GJ, Li, JJ, Deng, SM

   Solid multicomponent systems (SMS) are gaining an increasingly important role in the pharmaceutical industry, to improve the physicochemical properties of active pharmaceutical ingredients (APIs). In recent years, various processes have been employed for SMS manufacturing. Control of the particle...