Skip to main content
Join CMKC members for a complimentary virtual event on December 10, 11am ET: CM MythBusters: https://bit.ly/3YXJynA. This is a fantastic opportunity to connect, collaborate, and debunk common myths about continuous manufacturing!
18.191.103.144

Mathematical modeling and digital design of an intensified filtration-washing-drying unit for pharmaceutical continuous manufacturing

By Destro, Francesco; Hur, Inyoung Wang, Vivian Abdi, Mesfin; Feng, Xin; Wood, Erin; Coleman, Simon; Firth, Paul; Barton, Alastair; Barolo, Massimiliano; Nagy, Zoltan K.

Published on

Abstract

This paper introduces a comprehensive mathematical model of a novel integrated filter-dryer carousel system, designed for continuously filtering, washing and drying a slurry stream into a crystals cake. The simulator includes models for dead-end filtration, cake washing and convective cake drying, based on dynamic multi-component mass, energy and momentum balances. For a set of feed conditions and control inputs, the model allows tracking the solvents and impurities content in the cake (critical quality attributes, CQAs) throughout the whole process. The filtration and drying model parameters were identified for the isolation of paracetamol from a crystallization slurry. The calibrated model was used for designing the isolation of paracetamol from a multi-component slurry, containing a non-volatile impurity, too. The probabilistic design space, expressing the combinations of the carousel feed conditions and control inputs for which the probability of meeting the target CQAs is acceptable, and the maximum throughput were identified.

Journal

Chemical Engineering Science. Volume 244,, 2021, 116803

DOI

10.1016/j.ces.2021.116803

Type of publication

Peer-reviewed journal

Affiliations

  • Purdue University

Article Classification

Research Article

Classification Areas

  • Modelling

Tags