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A segmented flow platform for on-demand medicinal chemistry and compound synthesis in oscillating droplets

By Hwang, YJ; Coley, CWAbolhasani, M; Marzinzik, AL; Koch, G; Spanka, C; Lehmann, H; Jensen, KF

View Resource (DOI)

Category

Peer-reviewed journal

Published on

Abstract

We report an automated flow chemistry platform that can efficiently perform a wide range of chemistries, including single/multi-phase and single/multi-step, with a reaction volume of just 14 mu L. The breadth of compatible chemistries is successfully demonstrated and the desired products are characterized, isolated, and collected online by preparative HPLC/MS/ELSD.

Journal

Chemical Communications. Volume 53, 2017, 6649-6652

DOI

10.1039/c7cc03584e

Type of publication

Peer-reviewed journal

Affiliations

  • Massachusetts Institute of Technology (MIT) (MIT)
  • Inha University
  • North Carolina State University; Novartis Institute for Biomedical Research

Article Classification

Research Article

Classification Areas

  • API

Tags

  1. API
  2. Automated flow chemistry platform
  3. Preparative HPLC
  4. Research Article
  5. single/multiphase
  6. single multistage