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Near-infrared spectroscopic applications in pharmaceutical particle technology

By Razuc, M; Grafia, AGallo, L; Ramirez-Rigo, MV; Romanach, RJ

Published on

Abstract

Near-infrared spectroscopy (NIRS) is nowadays an established analytical technique in the pharmaceutical industry. The aim of this review is to present the progress of NIRS in providing useful information for pharmaceutical particle technology. NIR methods are now developed to characterize a wide variety of materials (active pharmaceutical ingredients, excipients, co-processed powders, and physical mixtures) and pharmaceutical dosage forms (conventional, modified drug release technologies, and phytomedicines). This review also provides a number of spectra to illustrate the fundamental understanding of NIRS which has been gained. The sampling that must occur prior to the acquisition of near-infrared spectra is also discussed, as well as developments in monitoring mixing, tableting, and coating. This review will be valuable for product formulation and process engineering specialists.

Journal

Drug Development and Industrial Pharmacy. Volume 45, 2019, 1565-1589

DOI

10.1080/03639045.2019.1641510

Type of publication

Peer-reviewed journal

Affiliations

  • Universidad Nacional del Sur
  • UniversitĂ© libre de Bruxelles (ULB)
  • University of Novi Sad (UNS), University of Puerto Rico

Article Classification

Review article

Classification Areas

  • API

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