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Nucleation kinetics of paracetamolethanol solutions from metastable zone widths

By Mitchell, Niall A.; Frawley, Patrick J.

Published on

Abstract

A study of the nucleation kinetics for a cooling crystallisation of paracetamolethanol solutions in a batch reactor is described in this paper. Metastable zone width (MSZW) experiments were conducted in order to estimate the nucleation kinetics of the system. Measured MSZWs can be affected by numerous process parameters, such as cooling rate, concentration, agitation rate, and working volume. Two theoretical approaches were employed to estimate the nucleation kinetics, the classical mass based approach of Nvlt, and a more recent approach by Kubota, which also considers number density. Both approaches were found to produce similar estimates for the nucleation rates of the paracetamolethanol solutions as a function of supersaturation for an assumed nucleus size of 10 μm. The theory of Kubota was found to predict satisfactory estimates for the induction time of the nucleation process from MSZW data. The induction time was observed to be independent of the solution temperature as suggested by Kubota's theory. This is a novel finding and serves to validate the induction time theory of Kubota. In this investigation, MSZWs were observed to decrease with increased levels of agitation and found to be independent of working volume. © 2010 Elsevier B.V. All rights reserved.

Journal

Journal of Crystal Growth. Volume 312, 19, 2010, 2740-2746

DOI

10.1016/j.jcrysgro.2010.05.043

Type of publication

Peer-reviewed journal

Affiliations

  • University of Limerick

Article Classification

Research Article

Classification Areas

  • Control

Tags