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Pharmaceutical industry perspectives on flow chemocatalysis and biocatalysis

By Martin, LL; Peschke, TVenturoni, F; Mostarda, S

Published on CMKC

Abstract

In response to a growing demand for more sustainable and cost-effective synthetic processes, the pharmaceutical industry is increasingly relying on continuous manufacturing as a valuable alternative to conventional batch processing. Particularly, flow processing may enable process intensification of chemocatalytic and biocatalytic transformations, both being of strategic importance on the design and production of active pharmaceutical ingredients. This review outlines the current status of flow chemocatalysis and biocatalysis within the pharmaceutical landscape. Furthermore, the trends and challenges that these technologies face are highlighted, based on recently disclosed applications from industry and innovative solutions from academia.

Journal

Current Opinion in Green and Sustainable Chemistry. Volume 25, 2020

DOI

10.1016/j.cogsc.2020.04.011

Type of publication

Peer-reviewed journal

Affiliations

  • Novartis Pharma AG

Article Classification

Review article

Classification Areas

  • API

Tags