Film thicknesses on film coated tablets have been predicted based on the assumption that the increase in volume of a tablet core after coating is a result of a uniform thickness of polymer coating, i.e. a calculation of the dry volume increase in film coating per unit area of a tablet surface will be equivalent to an average film thickness. The correlation between predicted and measured values is very good with predicted values being, on average, some 14% higher consistent with the fact that 100% coating efficiency is never achieved in practice.

• Zeneca Pharmaceuticals

• Oral solid dose

1. coated tablets
2. film thickness
3. oral solid dose
4. prediction
5. Research Article