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Qualitative Assessment of a Multi-Scale, Compartmental PBM-DEM Model of a Continuous Twin-Screw Wet Granulation Process

By Barrasso, Dana; Ramachandran, Rohit

Published on

Abstract

Wet granulation processes play a crucial role in solid oral dosage manufacturing processes. However, they are often designed empirically with poor efficiency. To implement quality-by-design, a more scientific understanding is desired to predict the effects of process and equipment design and material properties on the rate mechanisms governing wet granulation processes. In this study, a multi-dimensional compartmental population balance model of a twin screw granulation process is coupled with discrete element method simulations to evaluate mechanistic rate expressions describing aggregation, breakage, consolidation, and particle flow. Steady-state results are presented for various configurations of the screw elements. The effects of screw element configuration on product size distribution, porosity, and liquid distribution are presented and compared with experimental trends described in literature. Simulated results are consistent with experimental findings, demonstrating the model's qualitative ability to predict the effects of screw element design and configuration on the particle-scale phenomena and process outcomes.

Journal

Journal of Pharmaceutical Innovation. Volume 11, 3, 2016, 231 - 249

DOI

10.1007/s12247-015-9240-7

Type of publication

Peer-reviewed journal

Affiliations

  • Rutgers, The State University of New Jersey

Article Classification

Research article

Classification Areas

  • Oral solid dose

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