Continuous drug product manufacturing is slowly being implemented in the pharmaceutical industry. Although the benefits related to the quality and cost of continuous manufacturing are widely recognized, several challenges hampered the widespread introduction of continuous manufacturing of drug products. Current review presents an overview of state-of-the art Research Article, equipment, process analytical technology implementations and advanced control strategies. Additionally, guidelines and regulatory viewpoints on implementation of continuous manufacturing in the pharmaceutical industry are discussed.

• Ghent University

• PAT
• Oral solid dose
• Regulatory

1. Advanced process control
2. continuous manufacturing
3. Direct compression
4. oral solid dose
5. pat
6. Process analytical technology
7. regulatory
8. Review article
9. Roller compaction
10. Twin-screw granulation