A new system for continuous wet granulation and drying, based on a modified high-shear-mixer is investigated using met-formine, paracetamole and ibuprofene as active ingredients. First experiments reveal the excellent shape and particle size distribution of the granules. Tabletting investigations show that under all conditions tablets of sufficient tensile strength can be produced, which are comparable to those granulated in a batch high-shear mixer. The system fulfils high-containment requirements and can be equipped with WIP/CIP components and sensors for particle size and water content.

• University of Bonn

• Oral solid dose
• Process characteriztion

1. continuous granulation
2. High containment
3. High-shear-granulator
4. oral solid dose
5. Process characteriztion
6. Research Article
7. Vacuum dryer
8. wet granulation