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The Future of Pharmaceutical Manufacturing Sciences

By Rantanen, Jukka; Khinast Johannes

Published on

Abstract

The entire pharmaceutical sector is in an urgent need of both innovative technological solutions and fundamental scientific work, enabling the production of highly engineered drug products. Commercial-scale manufacturing of complex drug delivery systems (DDSs) using the existing technologies is challenging. This review covers important elements of manufacturing sciences, beginning with risk management strategies and design of experiments (DoE) techniques. Experimental techniques should, where possible, be supported by computational approaches. With that regard, state-of-art mechanistic process modeling techniques are described in detail. Implementation of materials science tools paves the way to molecular-based processing of future DDSs. A snapshot of some of the existing tools is presented. Additionally, general engineering principles are discussed covering process measurement and process control solutions. Last part of the review addresses future manufacturing solutions, covering continuous processing and, specifically, hot-melt processing and printing-based technologies. Finally, challenges related to implementing these technologies as a part of future health care systems are discussed.

Journal

Journal of Pharmaceutical Sciences. Volume 104, 2015, 3612-3638

DOI

10.1002/jps.24594

Type of publication

Peer-reviewed journal

Affiliations

  • University of Copenhagen
  • Graz University of Technology
  • Research Article Center Pharmaceutical Engineering

Article Classification

Review article

Classification Areas

  • PAT
  • API

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