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Twin screw granulation - review of current progress

By Thompson, M. R.

Published on

Abstract

Twin screw granulation (TSG) is a new process of interest to the pharmaceutical community that can continuously wet granulate powders, doing so at lower liquid concentrations and with better product consistency than found by a high shear batch mixer. A considerable body of Research Article has evolved over the short time since this process was introduced but generally with little comparison of results. A certain degree of confidence has been developed through these studies related to how process variables and many attributes of machinery configuration will affect granulation but some major challenges still lay ahead related to scalability, variations in the processing regimes related to degree of channel fill and the impact of wetting and granulation of complex powder formulations. This review examines the current literature for wet granulation processes studied in twin screw extrusion machinery, summarizing the influences of operational and system parameters affecting granule properties as well as strives to provide some practical observations to newly interested users of the technique.

Journal

Drug Development and Industrial Pharmacy. Volume 41, 8, 2015, 1223-1231

DOI

10.3109/03639045.2014.983931

Type of publication

Peer-reviewed journal

Affiliations

  • McMaster University

Article Classification

Review article

Classification Areas

  • Oral solid dose

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