Fully automated continuous flow synthesis of 4,5-disubstituted oxazoles

Baumann M; Baxandale. I; Ley S; Smith G; Tranmer G

Fully automated continuous flow synthesis of 4,5-disubstituted oxazoles

By Baumann M¹; Baxandale. I¹; Ley S¹; Smith G¹; Tranmer G¹

1. Innovative Technology Center, Department of Chemistry, University of Cambridge

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Published on CMKC

12 Oct 2023

Abstract

A multipurpose mesofluidic flow reactor capable of producing gram quantities of material has been developed as an automated synthesis platform for the rapid on-demand synthesis of key building blocks and small exploratory libraries. The reactor is configured to provide the maximum flexibility for screening of reaction parameters that incorporate on-chip mixing and columns of solid supported reagents to expedite the chemical synthesis.

Journal

Organic Letters

DOI

10.1021/ol061975c

Type of publication

Peer-reviewed Journal

Affiliations

Innovative Technology Center, Department of Chemistry, University of Cambridge

Article Classification

Research Article

Classification Areas

Chemical Synthesis