Twin-screw granulation (TSG) is an emerging process technology that allows both wet and dry granulation of powders with a wide range of properties. This technology is of particular interest to the pharmaceutical industry, which is currently aiming to shift from batch to continuous mode manufacturing. TSG found its roots in the late 1990s, evolved rapidly in the last decade as a promising wet granulation technology and was commercialized by some of the leading equipment manufacturers, such as GEA and ThermoFisher. Drying is the obvious downstream step of twin-screw wet granulation and is achieved mainly by a semi-continuous fluid-bed dryer [1]. While the early applications of TSG were focused on the wet granulation process, it is now gaining ground as an alternative dry granulation method, namely melt granulation [2]. This evolution of technology is also evident in this Special Issue, where articles related to both wet and melt granulation have found a place.

• Ghent University

• Oral solid dose

1. continuous manufacturing
2. oral solid dose
3. pharmaceutical processing
4. Review article
5. wet granulation