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Application of Continuous Flow Micromixing Reactor Technology for Synthesis of Benzimidazole Drugs

By Reddy, Gunupati Sharathchandra; Reddy, Narra Santosh; Manudhane, Kushal; Rama Krishna, Medisetti Venkata; Ramachandra, Kopparapu Janardana Sarma; Gangula, Srinivas

View Resource (DOI)

Category

Peer-reviewed journal

Published on CMKC

Abstract

Synthesis of pharmaceutically active compounds by employing continuous flow micromixing reactor technology is an interesting research area. In this article we describe the synthesis of benzimidazole core drugs, such as lansoprazole (1a), pantaprazole (1b), and rabeprazole (1c) by using a continuous flow micromixing reactor technology. A key feature of the sulfoxidation includes the decreasing the reaction time from 3 h to ∼1 s to minimize the formation of sulfone impurities and improve the yields.

Journal

Organic Process Research & Development. Volume 17, 2013, 1272-1276

DOI

10.1021/op300325f

Type of publication

Peer-reviewed journal

Affiliations

  • Dr. Reddy’s Laboratories Ltd.

Article Classification

Research Article

Classification Areas

  • API

Tags

  1. API
  2. Benzimidazole
  3. lansoprazole
  4. micromixing technology
  5. pantaprazole
  6. rabeprazole
  7. Research Article
  8. sulfoxidation