A flow-based synthesis of telmisartan
Category
Published on CMKC
Abstract
A highly efficient continuous synthesis has been developed for telmisartan, the active ingredient in the antihypertensive drug, Micardis. This synthetic route employs a convergent strategy that requires no intermediate purifications or solvent exchanges. The key step in the reaction scheme is a Suzuki cross-coupling reaction between two functionalized benzimidazoles that is catalyzed by a solid-supported Pd catalyst. This flow-based approach utilizes a tubular reactor system coupled with a plug flow packed bed cartridge unit that produces telmisartan in an 81% isolated yield.
Journal
Journal of Flow Chemistry. Volume 5, 2015, 145–147
DOI
10.1556/jfc-d-15-00002
Type of publication
Peer-reviewed journal
Affiliations
- Virginia Commonwealth University
Article Classification
Research Article
Classification Areas
- API