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Heating under High-Frequency Inductive Conditions: Application to the Continuous Synthesis of the Neurolepticum Olanzapine (Zyprexa)

By Hartwig, Jan; Ceylan, Sascha; Kupracz, Lukas; Coutable, Ludovic; Kirschning, Andreas

View Resource (DOI)

Category

Peer-reviewed journal

Published on

Abstract

Hot chemistry! High-frequency inductive heating and flow chemistry are an ideal match for high-temperature synthesis. This is demonstrated in the multistep flow synthesis of the neurolepticum olanzapine (Zyprexa) that included three reactions with inductive heating and two purification steps conducted as continuous processes.

Journal

Angewandte Chemie International Edition. Volume 52, 2013, 9813-9817

DOI

10.1002/anie.201302239

Type of publication

Peer-reviewed journal

Affiliations

  • Leibniz Universität Hannover

Article Classification

Research Article

Classification Areas

  • API

Tags

  1. API
  2. High-frequency inductive heating
  3. high-temperature synthesis
  4. Multistep flow synthesis
  5. Neurolepticum Olanzapine
  6. Research Article