Comparison of a Batch and Flow Approach for the Lipase-Catalyzed Resolution of a Cyclopropanecarboxylate Ester, A Key Building Block for the Synthesis of Ticagrelor
Category
Published on CMKC
Abstract
In this study a batch reactor process is compared to a flow chemistry approach for lipase-catalyzed resolution of the cyclopropanecarboxylate ester (±)-3. (1R,2R)-3 is a precursor of the amine (1R,2S)-2 which is a key building block of the API ticagrelor. For both flow and batch operation, the biocatalyst could be recycled several times, whereas in the case of the flow process the reaction time was significantly reduced.
Journal
Organic Process Research & Development. Volume 21, 2017, 195–199
DOI
10.1021/acs.oprd.6b00346
Type of publication
Peer-reviewed journal
Affiliations
- Chemessentia, SRL
- University of Leeds
- Manchester Institute Of Biotechnology
Article Classification
Research Article
Classification Areas
- Intermediate
- API