Comparison of a Batch and Flow Approach for the Lipase-Catalyzed Resolution of a Cyclopropanecarboxylate Ester, A Key Building Block for the Synthesis of Ticagrelor

Hugentobler, Katharina G.; Rasparini, Marcello; Thompson, Lisa A.; Jolley, Katherine E.; Blacker, A. John; Turner, Nicholas J.

Comparison of a Batch and Flow Approach for the Lipase-Catalyzed Resolution of a Cyclopropanecarboxylate Ester, A Key Building Block for the Synthesis of Ticagrelor

By Hugentobler, Katharina G.; Rasparini, Marcello; Thompson, Lisa A.; Jolley, Katherine E.; Blacker, A. John; Turner, Nicholas J.

View Resource (DOI)

Published on CMKC

23 Jul 2024

Abstract

In this study a batch reactor process is compared to a flow chemistry approach for lipase-catalyzed resolution of the cyclopropanecarboxylate ester (±)-3. (1R,2R)-3 is a precursor of the amine (1R,2S)-2 which is a key building block of the API ticagrelor. For both flow and batch operation, the biocatalyst could be recycled several times, whereas in the case of the flow process the reaction time was significantly reduced.

Journal

Organic Process Research & Development. Volume 21, 2017, 195–199

DOI

10.1021/acs.oprd.6b00346

Type of publication

Peer-reviewed journal

Affiliations

Chemessentia, SRL
University of Leeds
Manchester Institute Of Biotechnology

Article Classification

Research Article

Classification Areas

Intermediate
API