Development of a Continuous Flow Process for a Matteson Reaction: From Lab Scale to Full-Scale Production of a Pharmaceutical Intermediate
Category
Published on CMKC
Abstract
Within this paper, we present the design, development, and scale-up of a process for a continuous Matteson reaction to produce a key intermediate toward the β-lactamase inhibitor vaborbactam. This includes the successful implementation of the continuous concept at a multiton production scale for the API at Patheon, part of Thermo Fisher Scientific. The first-generation continuous flow production with its discontinuous downstream processing was further developed to a fully continuous production through installation of a continuous loop reactor. This enabled increased productivity and energy efficiency, eliminated volume and time bottlenecks, and reduced waste.
Journal
Organic Process Research & Development. Volume 23, 2019, 1069-1077
DOI
10.1021/acs.oprd.8b00340
Type of publication
Peer-reviewed journal
Affiliations
- Patheon Austria GmbH
- InnoSyn B.V.
- Qpex Biopharma, Inc.; Patheon Regensburg GmbH; Melinta Therapeutics
Article Classification
Research Article
Classification Areas
- Intermediate
- API