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Critical review on the role of excipient properties in pharmaceutical powder-to-tablet continuous manufacturing

By Sara Fathollahi1; Pauline H. M. Janssen2; Bastiaan H. J. Dickhoff1; Henderik W. Frijlink3

1. DFE Pharma 2. DFE Pharma, University of Groningen 3. University of Groningen

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Category

Peer-reviewed journal

Published on CMKC

Abstract

The pharmaceutical industry is gradually changing batch-wise manufacturing processes to continuous manufacturing processes, due to the advantages it has to offer. The final product quality and process efficiency of continuous manufacturing processes is among others impacted by the properties of the raw materials. Existing knowledge on the role of raw material properties in batch processing is however not directly transferable to continuous processes, due to the inherent differences between batch and continuous processes.

Journal

Expert Opinion on Drug Delivery

DOI

10.1080/17425247.2024.2384698

Type of publication

Open Access Journal

Affiliations

  • DFE Pharma
  • University of Groningen

Article Classification

Review article

Classification Areas

  • Oral Solid Dosage

Tags

  1. continuous manufacturing
  2. continuous processing
  3. Excipients
  4. Lactose
  5. Material characterization
  6. Material properties
  7. Microcrystalline cellulose
  8. quality by design