Traditionally the manufacturing of pharmaceutical dosage forms has been a batch-wise process and continuous processes have limited applications in a pharmaceutical manufacturing plant. However, several factors (reduction of cost, improved process efficiency, optimal use of equipment, flexibility in production capacity) are stimulating the pharmaceutical industry to investigate the opportunities offered by continuous processes. This paper discusses some of the techniques which could be implemented in a continuous granulation process of pharmaceuticals.

• Ghent University
• Karl Franzens University Graz

• Oral Solid Dose

1. Agglomeration
2. extrusion
3. fluid bed
4. oral solid dose
5. Research Article
6. Roller compaction
7. solid dosage forms
8. Spray - drying