The continuous manufacturing of pharmaceutical compounds and fine chemicals is in high interest for the industry due to significant technical, quality, and economical advantages. This manufacturing method has its own challenges. Beside the more efficient, safer, and greener synthesis rout, a new process design paradigm and equipment selection and design is required. Defining system dynamic to correlate critical quality attribute of final product to critical process parameters is crucial for ensuring consistence product quality and process robustness. This work will provide a high-level overall view on the advantages and challenges of continuous manufacturing and review the process and equipment design considerations.

• Procegence LLC

• PAT
• API

1. API
2. Continuous crystallization
3. continuous manufacturing
4. Drug substance
5. flow chemistry
6. pat
7. Process design
8. Process intensification
9. Review article