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Continuous twin screw granulation - An advanced alternative granulation technology for use in the pharmaceutical industry

By Bandari, Suresh; Nyavanandi, Dinesh; Kallakunta, Venkata Raman; Janga, Kartik Yadav; Sarabu, Sandeep; Butreddy, Arun; Repka, Michael A.

Published on

Abstract

Hot melt extrusion has been an exciting technology in the pharmaceutical field owing to its novel applicability. Twin-screw granulation presents a great potential and offers many advantages relative to conventional granulation processes. Different twin-screw granulation techniques, such as twin-screw dry granulation, twin-screw wet granulation, and twin-screw melt granulation, are currently being developed as robust and reproducible granulation processes. The competence of twin-screw granulation as a continuous manufacturing process has contributed to its suitability as an alternative granulation option within the pharmaceutical industry. In this article, different types of twin-screw granulation techniques were discussed. In addition, the screw elements, scale-up process, continuous twin-screw granulation which involves process analytical tools, and excipients were explored. This economical, industrially scalable process can be automated for continuous manufacturing to produce granules for the development of oral solid dosage forms. However, extensive Research Article using process analytical tools is warranted to develop processes for the continuous manufacture of granules.

Journal

International Journal of Pharmaceutics. Volume 580, 2020, 119215

DOI

10.1016/j.ijpharm.2020.119215

Type of publication

Peer-reviewed journal

Affiliations

  • University of Mississippi
  • Bayer Healthcare LLC

Article Classification

Review article

Classification Areas

  • PAT
  • Oral solid dose

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