A generic model-based framework has been developed for crystallization processes, with applications aiming at the control of process operations and the monitoring of product quality. This generic model-based framework allows the systematic development of a wide range of crystallization models for different operational scenarios. This enables the design and control engineers to analyze various crystallization operations and conditions, thus facilitating the development of process control and monitoring systems (PAT systems) for crystallization processes. The generic framework has been implemented in the ICAS-PAT software which allows the user to design and validate PAT systems through a systematic computer-aided framework. The application of the framework is highlighted for batch cooling crystallization of paracetamol where the framework was applied for design of a process monitoring and control system to obtain a desired crystal size distribution (CSD).

• Rutgers, The State University of New Jersey

• Oral doses
• Modeling

1. crystallization
2. crystal size distribution (CSD)
3. modeling
4. N/A
5. Oral doses
6. paracetamol
7. pat
8. Process monitoring and control
9. Research Article