Direct compaction (DC) is the preferred choice for tablet manufacturing; however, only less than 20% of active pharmaceutical ingredients could be compacted via DC as its high requirement for functional properties of materials. Materials with improper functionalities could lead to serious troubles during DC manufacturing, such as content non-uniformity, sticking, and capping, all of which profoundly affect the properties of final products and, thus, severely restrict the practical application of DC. With undoubted importance, these seem to be unexpectedly ignored by reviewers but not Research Articleers in terms of many original Research Article articles published recently. Therefore, as an informative supplement and update, this review mainly focused on trouble-shooting and application situation of DC, together with several newly reported materials. (C) 2017 Elsevier B.V. All rights reserved.

• Shanghai University of Traditional Chinese Medicine

• API
• Process control
• Oral Dosis

1. API
2. Application
3. Capping
4. Content uniformity
5. Directly compressible materials
6. Oral Dosis
7. process control
8. Review article
9. Sticking