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Dynamic Plantwide Modeling, Uncertainty, and Sensitivity Analysis of a Pharmaceutical Upstream Synthesis: Ibuprofen Case Study

By Montes, Frederico C.C.; Gernaey, Krist; Sin, Gürkan

Published on CMKC

Abstract

A dynamic plantwide model was developed for the synthesis of the active pharmaceutical ingredient (API) ibuprofen, following the Hoescht synthesis process. The kinetic parameters, reagents, products, and byproducts of the different reactions were adapted from literature, and the different process operations were integrated until the end process, crystallization, and isolation of the ibuprofen crystals. The dynamic model simulations were validated against available measurements from literature and then used as an enabling tool to analyze the robustness of design space. To this end, the sensitivity of the design space toward input disturbances and process uncertainties (from physical and model parameters) is studied using Monte Carlo simulations. The results quantify the uncertainty of the quality of product attributes, with particular focus on crystal size distribution and ibuprofen crystallization. The ranking of the most influential parameters on the chosen quality attributes is presented, with crystal growth and water concentration being the most influential ones. The total amount of saturated solvent, which propagates from upstream processes, has been shown to highly influence the total mass of crystal produced and the underspecified API as well. This dynamic plantwide modeling coupled with Monte Carlo simulations is valuable to improve the design and optimization of pharmaceutical processes at early stages, especially to bottleneck the design space against a range of uncertainties and disturbances.

Journal

Industrial & Engineering Chemistry Research. Volume 57, 30, 2018, 10026-10037

DOI

10.1021/acs.iecr.8b00465

Type of publication

Peer-reviewed journal

Affiliations

  • Technical University of Denmark (Prosys)

Article Classification

Research Article

Classification Areas

  • Modeling

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