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End-to-End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation

By Mascia, Salvatore; Heider, Patrick L.; Zhang, Haitao; Lakerveld, Richard; Benyahia, Brahim; Barton, Paul I.; Braatz, Richard D.; Cooney, Charles L.; Evans, James M. B.; Jamison, Timothy F.; Jensen, Klavs F.; Myerson, Allan S.; Trout, Bernhardt L.

View Resource (DOI)

Category

Peer-reviewed journal

Published on CMKC

Abstract

A series of tubes: The continuous manufacture of a finished drug product starting from chemical intermediates is reported. The continuous pilot-scale plant used a novel route that incorporated many advantages of continuous-flow processes to produce active pharmaceutical ingredients and the drug product in one integrated system.

Journal

Angewandte Chemie International Edition. Volume 52, 2013, 12359-12363

DOI

10.1002/anie.201305429

Type of publication

Peer-reviewed journal

Affiliations

  • Massachusetts Institute of Technology (MIT) (MIT)

Article Classification

Research article

Classification Areas

  • PAT
  • Oral solid dose

Tags

  1. End-to-End Continuous Manufacturing ofPharmaceuticals
  2. Final Dosage Formation
  3. Integrated Synthesis
  4. oral solid dose
  5. pat
  6. purification
  7. Research Article