The feed frame is a force-feeding device used in the die filling process. The die filling process is crucial within pharmaceutical manufacturing to guarantee the critical quality attributes of the tablets. In recent years, interest in this unit has increased because it can affect the properties of the powder blend and tablets, and because of the success in real time monitoring of powder blend uniformity potential for Process Analytical Technology as described in this review. The review focuses on the recent advances in understanding the powder flow behavior inside the feed frame and how the residence time distribution of the powder within the feed frame is affected by the operating conditions and design parameters. Furthermore, this review also highlights the effect of the paddle wheel design and feed frame process parameters on the tablet weight, the principal variable for measuring die filling performance.

• University of Puerto Rico at Mayagüez

• PAT
• Oral solid dose

1. Feed frame
2. Forced feeder
3. oral solid dose
4. pat
5. Powder flow behavior
6. Process analytical technology (PAT)
7. residence time distribution
8. Review article
9. Tableting process / Continuous manufacturing