Continuous manufacturing for the production of pharmaceutical products is emerging as a key technology due to the advantages it has over traditional batch manufacturing methods. Process systems engineering is critical in rolling out this technology within the industry since it allows for more robust process development and can address regulatory concerns such as the need for quality by design. In this chapter, the use of flowsheet models applied to continuous direct compression is discussed. The unit operations involved in the process are outlined as well as the modeling approaches that can be adopted. Powder feeding is identified as the most important unit operation for maintain product quality and powder blending's role in smoothing out potential feeding disturbances is discussed.

• University of Massachusetts Lowell

• Process Control and modeling

1. COMPACTION BEHAVIOR
2. DEM/CFD ANALYSIS
3. Powder flow
4. Process Control and modeling
5. Research Article
6. simulations
7. SIZE
8. Tablets