Optimizing current chemical processes alone does not yield the improvements required in the fine chemical and pharmaceutical industries. At least partially, a switch from batch to continuous manufacturing is needed. Cost-, time-, and atom-efficient routes frequently demand the application of high temperatures, pressures, and concentrations, and/or the use of highly reactive reagents. These chemistries often cannot be employed in conventional reactors. Costly and long alternative synthetic routes are chosen instead. The application of continuous-flow microreactors allows to access "harsh" or "hazardous" reaction conditions and, furthermore, enables entirely new transformations.

• Graz University
• Research Center Pharmaceutical Engineering GmbH RCPE

• API

1. Active pharmaceutical ingredients
2. API
3. continuous processing
4. extreme conditions
5. microreactors
6. Process intensification
7. Research Article