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A Perspective on Continuous Flow Chemistry in the Pharmaceutical Industry

By Baumann, M; Moody, TSSmyth, M; Wharry, S

Published on

Abstract

Continuous flow manufacture is an innovative technology platform, which is gaining momentum within the pharmaceutical industry. The key advantages of continuous flow include faster and safer reactions, which can be more environmentally friendly, smaller footprint, better quality product, and critically, the ability to perform chemistry that is difficult or impossible to do in batch mode. Globally, significant efforts have been made to develop the manufacturing flexibility and robustness of processes used to produce chemicals in a continuous way, yet despite these scientific developments, a major challenge for industry is the established application of flow technology to commercially relevant examples. The identification of opportunities to apply flow solutions to current processes is also critical to the success of this new technology for pharmaceutical and fine chemical companies. This review highlights industrial hurdles and the importance of education and showcases recent (2018-2019) and relevant industrial examples where utilization of flow technology has been successfully performed.

Journal

Organic Process Research & Development. Volume 24, 2020, 1802-1813

DOI

10.1021/acs.oprd.9b00524

Type of publication

Peer-reviewed journal

Affiliations

  • Almac Group Ltd
  • Arran Chemical Company
  • University College Dublin

Article Classification

Review article

Classification Areas

  • API

Tags