Development and Scale-Up of Three Consecutive Continuous Reactions for Production of 6-Hydroxybuspirone
Contributor(s):: LaPorte, Thomas L., Hamedi, Mourad, DePue, Jeffrey S., Shen, Lifen, Watson, Daniel, Hsieh, Daniel
This paper describes the development of a continuous, high yielding, and scalable enolization, oxidation, and quench process for the hydroxylation of the azapirone psychtropic agent buspirone to afford 6-hydroxybuspirone...