Chemoenzymatic Synthesis in Flow Reactors: A Rapid and Convenient Preparation of Captopril
Contributor(s):: De Vitis, Valerio, Dall'Oglio, Federica, Pinto, Andrea, De Micheli, Carlo, Molinari, Francesco, Conti, Paola, Romano, Diego, Tamborini, Lucia
The chemoenzymatic flow synthesis of enantiomerically pure captopril, a widely used antihypertensive drug, is accomplished starting from simple, inexpensive, and readily available reagents. The first step is a heterogeneous biocatalyzed regio- and stereoselective oxidation of cheap prochiral...