All Categories (1-2 of 2)

1. Separation of Chemical Reaction Intermediates by Metal-Organic Frameworks

   out of 5 stars 

   Contributor(s):: Centrone, A, Santiso, EE, Hatton, TA

   HPLC columns custom-packed with metal-organic framework (MOF) materials are used for the separation of four small intermediates and byproducts found in the commercial synthesis of an important active pharmaceutical ingredient in methanol. In particular, two closely related amines can be separated...

2. Life cycle analysis of solvent reduction in pharmaceutical synthesis using continuous adsorption for palladium removal

   out of 5 stars 

   Contributor(s):: Slater, CS, Savelski, MJ, Ruiz-Felix, MN

   The life cycle emissions associated with the reduction of wastes from an adsorption process to remove palladium complexes in drug manufacture have been evaluated. The study assessed a green improvement to a process step in an active pharmaceutical ingredient synthesis where palladium catalyst is...