Development and Scale-Up of a Continuous Aerobic Oxidative Chan-am Coupling
09 Jun 2023 | Contributor(s):: Brewer, AC, Hoffman, PCMartinelli, JR, Kobierski, ME, Mullane, N, Robbins, D
Despite the benefits of high atom economy and low cost, aerobic oxidations have found limited use in the synthesis of active pharmaceutical ingredients (APIs) because of safety concerns and poor selectivity. In this report, the design, development, and scale-up of a continuous, high pressure...
Aerobic oxidations in flow: opportunities for the fine chemicals and pharmaceuticals industries
09 Jun 2023 | Contributor(s):: Gavriilidis, A, Constantinou, AHellgardt, K, Hii, KK, Hutchings, GJ, Brett, GL, Kuhn, S, Marsden, SP
Molecular oxygen is without doubt the greenest oxidant for redox reactions, yet aerobic oxidation is one of the most challenging to perform with good chemoselectivity, particularly on an industrial scale. This collaborative review (between teams of chemists and chemical engineers) describes the...