Tailoring the crystal size distribution of an active pharmaceutical ingredient by continuous antisolvent crystallization in a planar oscillatory flow crystallizer
Contributor(s):: Cruz, P, Alvarez, CRocha, F, Ferreira, A
An active pharmaceutical ingredient is currently produced in a traditional batch antisolvent crystallization process. Although well-established, this process lacks flexibility to control the crystal size distribution (CSD). Therefore, a new process was developed to enable the control of the CSD...
Modeling a seeded continuous crystallizer for the production of active pharmaceutical ingredients
Contributor(s):: Besenhard, M. O., Hohl, R. Hodzic, A. Eder, R. J.P., Khinast, J. G.
The approximation of a well mixed reactor is prevalent when it comes to the modeling of a crystallization process. Since temperature, concentration, and mass content vary due to inhomogeneous mixing, this approximation is a very loose one. The continuously operated seeded tubular crystallizer...