Synthesis of the Brivaracetam Employing Asymmetric Photocatalysis and Continuous Flow Conditions
Contributor(s):: Franco, Marcelo S., Silva, Rodrigo C., Rosa, Gabriel H. S., Flores, Lara M., Oliveira, Kleber T. de, Assis, Francisco F. de
An original total synthesis of the antiepileptic drug brivaracetam (BRV) is reported. The key step in the synthesis consists of an enantioselective photochemical Giese addition, promoted by visible-light and the chiral bifunctional photocatalyst Δ-RhS. Continuous flow conditions were employed to...
7-Step Flow Synthesis of the HIV Integrase Inhibitor Dolutegravir
| Contributor(s):: Ziegler, RE, Desai, BKJee, JA, Gupton, BF, Roper, TD, Jamison, TF
Dolutegravir (DTG), an important active pharmaceutical ingredient (API) used in combination therapy for the treatment of HIV, has been synthesized in continuous flow. By adapting the reported GlaxoSmithKline process chemistry batch route for Cabotegravir, DTG was produced in 4.5h in sequential...