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Why flow means green - Evaluating the merits of continuous processing in the context of sustainability
09 Jun 2023 | Contributor(s):: Dallinger, D, Kappe, CO
Enhanced heat and mass transfer, precise residence time control, shorter process times, increased safety, reproducibility, better product quality and easy scalability are just a few of the advantages of flow chemistry and reason for the increasing implementation of continuous processes not only...
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Impact of continuous flow chemistry in the synthesis of natural products and active pharmaceutical ingredients
09 Jun 2023 | Contributor(s):: De;Souza, JM, Galaverna, RDe, Souza, AAN, Brocksom, TJ, Pastre, JC, De, Souza, ROMA, De;Oliveira, KT
We present a comprehensive review of the advent and impact of continuous flow chemistry with regard to the synthesis of natural products and drugs, important pharmaceutical products and definitely responsible for a revolution in modem healthcare. We detail the beginnings of modern drugs and the...
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Formation of organic molecular nanocrystals under soft confinement
09 Jun 2023 | Contributor(s):: Yang, XC, Ong, TCMichaelis, VK, Heng, S, Griffin, RG, Myerson, AS
Methods to produce nano-sized organic molecular crystals in thin films are of great interest in the pharmaceutical industry due to the potential benefit of increased solubility of poorly soluble drugs and the advantages of film-based dosage forms over traditional tablet/capsule-based dosage...
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Detailed Analysis of the Online Near-Infrared Spectra of Pharmaceutical Blend in a Rotary Tablet Press Feed Frame
09 Jun 2023 | Contributor(s):: Šašić, Slobodan, Blackwood, Daniel, Liu, Angela, Ward, Howard W, Clarke, Hugh
The present study is an in-depth analysis of the online near-infrared (NIR) spectra acquired with a spectrometer mounted on the rotary tablet press feed frame. A 3.5% active pharmaceutical ingredient (API) formulation is analyzed. An attempt is made to determine the API univariately via the 2nd...