Development and process scaling of repeat mini-blending as a complementary approach to deliver continuous direct compression
Peer-reviewed journal | 13 Nov 2024 | Contributor(s):: Martin Prostredny, Hikaru Graeme Jolliffe, Richard Elkes, Khalid Maqsood, Yunfei Li Song, Gavin Reynolds, Bernhard Meir, John Robertson
Process integration efforts in the pharmaceutical industry have led to an increased interest in Direct Compression, including Continuous Direct Compression. Accurate scale-up of powder blending and prediction of blend Critical Quality Attributes (CQAs) is key. The present work takes a modified...
Challenges in tracing material flow passing a loss-in-weight feeder in continuous manufacturing processes
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Peterwitz, Moritz, Gerling, Sina, Schembecker, Gerhard
Loss-in-weight feeders are an integral part of most continuous manufacturing processes, ensuring a constant mass flow. The feeders cause a significant degree of back-mixing in such lines. Understanding back-mixing is essential for the treatment of disturbances. However, feeders refilled...