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1. Evaluating the potential for optimization of axial back-mixing in continuous pharmaceutical manufacturing

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   09 Jun 2023 | Contributor(s):: Peterwitz, M, Schembecker, G

   In continuous pharmaceutical manufacturing, the degree of back-mixing has two contrary effects on the propagation of disturbances through a process. Firstly, back-mixing results in the contamination of adjacent material by strong disturbances and additional losses. However, the available...

2. Challenges in tracing material flow passing a loss-in-weight feeder in continuous manufacturing processes

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   09 Jun 2023 | Contributor(s):: Peterwitz, Moritz, Gerling, Sina, Schembecker, Gerhard

   Loss-in-weight feeders are an integral part of most continuous manufacturing processes, ensuring a constant mass flow. The feeders cause a significant degree of back-mixing in such lines. Understanding back-mixing is essential for the treatment of disturbances. However, feeders refilled...