The effect of screw configuration and formulation variables on liquid requirements and granule quality in a continuous twin screw wet granulation process
09 Jun 2023 | Contributor(s):: Vandevivere, L., Van Wijmeersch, E., Hausler, O., De Beer, T., Vervaet, C., Vanhoorne, V.
The effect of two screw configurations with varying stagger angle was evaluated on the liquid amount required to produce good quality granules for a highly (mannitol-based) and a poorly (DCP-based) soluble formulation containing different binders. It is generally known that the use of a higher...